Effects of acute ingestion of salbutamol during submaximal exercise

Int J Sports Med. 2000 Oct;21(7):480-4. doi: 10.1055/s-2000-7422.


To assess the eventual effects of acute oral salbutamol intake on performance and metabolism during submaximal exercise, nine healthy volunteers completed two cycling trials at a power corresponding to 80-85% VO2max, after either placebo (Pla) or salbutamol (Sal, 6 mg) treatment, according to a double-blind randomized protocol. Blood samples were collected both at rest and during exercise (5 min-, 10 min-, 15 min-exhaustion) for C-peptide, FFA, lactate and blood glucose measurements. Cycling performance was significantly improved in the Sal vs. Pla trials (p < 0.05). After Sal intake, resting C-peptide, lactate, FFA and blood glucose values were higher whereas exercise lactate and free fatty acid concentrations were greater during and at the conclusion of the exercise period (p < 0.05). These results suggest that acute salbutamol ingestion improved performance during submaximal exercise probably through an enhancement of the overall contribution to energy production from both aerobic and anaerobic metabolisms.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Adrenergic beta-Agonists / administration & dosage*
  • Adult
  • Albuterol / administration & dosage*
  • Bicycling
  • Blood Glucose / analysis
  • C-Peptide / blood
  • Double-Blind Method
  • Energy Metabolism / drug effects
  • Exercise Tolerance / drug effects*
  • Fatty Acids, Nonesterified / blood
  • Humans
  • Lactates / blood
  • Male


  • Adrenergic beta-Agonists
  • Blood Glucose
  • C-Peptide
  • Fatty Acids, Nonesterified
  • Lactates
  • Albuterol