Increased skin lactate in complex regional pain syndrome: evidence for tissue hypoxia?

Neurology. 2000 Oct 24;55(8):1213-5. doi: 10.1212/wnl.55.8.1213.


To investigate oxygen metabolism in complex regional pain syndrome (CRPS), the authors measured skin lactate via dermal microdialysis performed on patients with CRPS (n = 11) and healthy control subjects (n = 11). In addition, they measured blood lactate. Although venous lactate was unaltered, skin lactate was increased in patients with CRPS (2.95 mmol/L; control subjects 1.74 mmol/L; p < 0.005). These results suggest enhanced anaerobic glycolysis, probably as a result of chronic tissue hypoxia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Female
  • Humans
  • Hypoxia / metabolism*
  • Lactic Acid / blood
  • Lactic Acid / metabolism*
  • Male
  • Microdialysis
  • Middle Aged
  • Reflex Sympathetic Dystrophy / blood
  • Reflex Sympathetic Dystrophy / metabolism*
  • Skin / metabolism*


  • Lactic Acid