Structure and expression of the human glycosylphosphatidylinositol phospholipase D1 (GPLD1) gene

Biochim Biophys Acta. 2000 Nov 15;1494(1-2):189-94. doi: 10.1016/s0167-4781(00)00194-9.


Here we report the structure of the human glycosylphosphatidylinositol phospholipase D1 gene, which covers at least 80 kb on chromosome 6p22. The gene comprises 25 exons and encodes a 5.8 kb mRNA, which was detected only in the liver. Southern blot analysis shows that the human genome contains only one GPLD gene and we could only detect one of the two previously reported cDNAs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Blotting, Southern
  • Exons / genetics*
  • Expressed Sequence Tags
  • Gene Dosage
  • Humans
  • Liver / enzymology*
  • Liver / metabolism
  • Molecular Sequence Data
  • Organ Specificity
  • Phospholipase D / chemistry
  • Phospholipase D / genetics*
  • RNA Splice Sites / genetics
  • RNA, Messenger / analysis
  • RNA, Messenger / genetics


  • RNA Splice Sites
  • RNA, Messenger
  • Phospholipase D
  • glycoprotein phospholipase D

Associated data

  • GENBANK/L11702