Methamphetamine-induced apoptosis is attenuated in the striata of copper-zinc superoxide dismutase transgenic mice

Brain Res Mol Brain Res. 2000 Nov 10;83(1-2):121-4. doi: 10.1016/s0169-328x(00)00169-8.

Abstract

Administration of methamphetamine caused significant increases in terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL)-positive cells, in poly (ADP-ribose) polymerase (PARP) cleavage, as well as in caspase-3 activity in the striata of C57BL/6J mice. In contrast, all these effects were markedly suppressed in the copper-zinc superoxide dismutase transgenic mice. These results indicate that superoxide radicals might be important factors in METH-induced cell death.

MeSH terms

  • Animals
  • Apoptosis / drug effects*
  • Apoptosis / physiology
  • Caspase 3
  • Caspases / metabolism
  • Central Nervous System Stimulants / pharmacology*
  • Corpus Striatum / cytology*
  • Corpus Striatum / drug effects
  • Corpus Striatum / enzymology
  • In Situ Nick-End Labeling
  • Male
  • Methamphetamine / pharmacology*
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Neurons / cytology
  • Neurons / drug effects
  • Neurons / enzymology
  • Poly (ADP-Ribose) Polymerase-1
  • Poly(ADP-ribose) Polymerases
  • Proteins / metabolism
  • Superoxide Dismutase / genetics*
  • Superoxide Dismutase / metabolism
  • Superoxides / metabolism

Substances

  • Central Nervous System Stimulants
  • Proteins
  • Superoxides
  • Methamphetamine
  • Superoxide Dismutase
  • Parp1 protein, mouse
  • Poly (ADP-Ribose) Polymerase-1
  • Poly(ADP-ribose) Polymerases
  • Casp3 protein, mouse
  • Caspase 3
  • Caspases