Abstract
Administration of methamphetamine caused significant increases in terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL)-positive cells, in poly (ADP-ribose) polymerase (PARP) cleavage, as well as in caspase-3 activity in the striata of C57BL/6J mice. In contrast, all these effects were markedly suppressed in the copper-zinc superoxide dismutase transgenic mice. These results indicate that superoxide radicals might be important factors in METH-induced cell death.
MeSH terms
-
Animals
-
Apoptosis / drug effects*
-
Apoptosis / physiology
-
Caspase 3
-
Caspases / metabolism
-
Central Nervous System Stimulants / pharmacology*
-
Corpus Striatum / cytology*
-
Corpus Striatum / drug effects
-
Corpus Striatum / enzymology
-
In Situ Nick-End Labeling
-
Male
-
Methamphetamine / pharmacology*
-
Mice
-
Mice, Inbred C57BL
-
Mice, Transgenic
-
Neurons / cytology
-
Neurons / drug effects
-
Neurons / enzymology
-
Poly (ADP-Ribose) Polymerase-1
-
Poly(ADP-ribose) Polymerases
-
Proteins / metabolism
-
Superoxide Dismutase / genetics*
-
Superoxide Dismutase / metabolism
-
Superoxides / metabolism
Substances
-
Central Nervous System Stimulants
-
Proteins
-
Superoxides
-
Methamphetamine
-
Superoxide Dismutase
-
Parp1 protein, mouse
-
Poly (ADP-Ribose) Polymerase-1
-
Poly(ADP-ribose) Polymerases
-
Casp3 protein, mouse
-
Caspase 3
-
Caspases