No association of serum levels of interleukin-6 and its soluble receptor components with a genetic variation in the 3'flanking region of the interleukin-6 gene in patients with multiple sclerosis

Neurosci Lett. 2000 Nov 24;294(3):139-42. doi: 10.1016/s0304-3940(00)01560-3.


Interleukin-6 (IL-6) plays an important role in the regulation of the inflammatory response in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Previous reports indicated that a variable number tandem repeat (vntr) polymorphism in the 3'flanking region of the IL-6 gene (C allele) is associated with altered activity of IL-6 in vivo. Therefore, we analyzed the frequency distribution of IL-6 gene C allele vntr poymorphism in 96 MS patients and 106 ethnically matched healthy controls. Moreover, possible correlations between genotypic differences of IL-6 gene and serum levels of IL-6, soluble IL-6 receptor (sIL6-R), soluble gp130 (sgp130), soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) were investigated. There were no differences in the allelic distribution of the IL-6 gene C allele between MS patients and healthy controls, and no association of the IL-6 gene C allele with serum levels of IL-6, sIL-6R, spg130, sICAM and sVCAM-1 was found.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Alleles*
  • Analysis of Variance
  • Antigens, CD / blood
  • Cytokine Receptor gp130
  • Female
  • Humans
  • Intercellular Adhesion Molecule-1 / blood
  • Interleukin-6 / blood
  • Interleukin-6 / genetics*
  • Logistic Models
  • Male
  • Membrane Glycoproteins / blood
  • Middle Aged
  • Multiple Sclerosis / blood
  • Multiple Sclerosis / genetics*
  • Polymorphism, Genetic / genetics*
  • Receptors, Interleukin-6 / blood*
  • Vascular Cell Adhesion Molecule-1 / blood


  • Antigens, CD
  • IL6ST protein, human
  • Interleukin-6
  • Membrane Glycoproteins
  • Receptors, Interleukin-6
  • Vascular Cell Adhesion Molecule-1
  • Intercellular Adhesion Molecule-1
  • Cytokine Receptor gp130