Pancreatic tumors show high levels of hypoxia

Int J Radiat Oncol Biol Phys. 2000 Nov 1;48(4):919-22. doi: 10.1016/s0360-3016(00)00803-8.


Purpose: Because of the dismal outcomes of conventional therapies for pancreatic carcinomas, we postulated that hypoxia may exist within these tumors.

Methods and materials: Seven sequential patients with adenocarcinomas of the pancreas consented to intraoperative measurements of tumor oxygenation using the Eppendorf (Hamburg, Germany) polargraphic electrode.

Results: All 7 tumors demonstrated significant tumor hypoxia. In contrast, adjacent normal pancreas showed normal oxygenation.

Conclusion: Tumor hypoxia exists within pancreatic cancers.

MeSH terms

  • Aged
  • Cell Hypoxia*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Oxygen / analysis*
  • Pancreas / chemistry*
  • Pancreas / physiology
  • Pancreatic Neoplasms / chemistry*
  • Pancreatic Neoplasms / physiopathology
  • Partial Pressure


  • Oxygen