Treatment of Alzheimer's disease: rationale and strategies

Neurol Clin. 2000 Nov;18(4):807-28. doi: 10.1016/s0733-8619(05)70227-9.


This article reviews the rationale and provides a progress update regarding the major treatment strategies being developed for the prevention and treatment of Alzheimer's disease. Various therapeutic areas are discussed, including acetylcholinesterase inhibitors and other cholinergic agents, antioxidants, anti-inflammatory drugs, hormone replacement therapy, antiamyloid treatment, and neurotrophic agents.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Aged
  • Alzheimer Disease / diagnosis
  • Alzheimer Disease / drug therapy*
  • Alzheimer Disease / etiology
  • Brain / drug effects
  • Clinical Trials as Topic
  • Humans
  • Neurons / drug effects
  • Nootropic Agents / adverse effects
  • Nootropic Agents / therapeutic use*


  • Nootropic Agents