Interdependence of filamentous actin and microtubules for asymmetric cell division

Biol Chem. 2000 Sep-Oct;381(9-10):815-25. doi: 10.1515/BC.2000.104.


Asymmetric cell divisions are crucial to the generation of cell fate diversity. They contribute to unequal distribution of cellular factors to the daughter cells. Asymmetric divisions are characterized by a 90 degrees rotation of the mitotic spindle. There is increasing evidence that a tight cooperation between cortical, filamentous actin and astral microtubules is indispensable for successful spindle rotation. Over the past years, the dynactin complex has emerged as a key candidate to mediate actin/microtubule interaction at the cortex. This review discusses our current understanding of how spindle rotation is accomplished by the interplay of filamentous actin and microtubules in a variety of experimental systems.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actins / physiology*
  • Animals
  • Cell Division / physiology
  • Humans
  • Microtubules / physiology*
  • Saccharomyces cerevisiae / physiology


  • Actins