[Irradiation of cornea with ultraviolet light and riboflavin administration as a new treatment for erosive corneal processes, preliminary results in four patients]

Klin Monbl Augenheilkd. 2000 Sep;217(3):190-3. doi: 10.1055/s-2000-10344.
[Article in German]


Background: Corneal melting is a serious condition and in many cases maybe managed only by surgery. UV-radiation with Riboflavin is a new method that may stop the melting process of the cornea.

Patients and method: Four patients suffering from melting ulcera of the cornea of various origin underwent a single UV-radiation. Two ultraviolet diodes were used emitting light with an wavelength of 370 nm with an energy of 2.5 mW/cm2. The radiation time was 30 minutes. Before he radiation was performed 2-3 drops of 0.11% Riboflavinsolution were applied to the cornea. The treatment area was 6-7 mm in diameter.

Results: After the treatment in three of the four patients the melting process of the cornea stopped. At least temporarily, a surgical procedure could be delayed.

Conclusion: Because of the absence of any side-effects in serious cases the method is recommended prior to surgery.

Publication types

  • Case Reports
  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Corneal Ulcer / drug therapy*
  • Corneal Ulcer / radiotherapy*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Ophthalmic Solutions
  • Photosensitizing Agents / administration & dosage*
  • Riboflavin / administration & dosage*
  • Treatment Outcome
  • Ultraviolet Therapy / methods*


  • Ophthalmic Solutions
  • Photosensitizing Agents
  • Riboflavin