Abstract
A novel quinolone, pinolinone (1); seven new phenylpropanoids, boropinols A (2), B (3), C (4), boropinals A (5), B (6), C (7), and boropinic acid (8); and a new lignan, boropinan (9), were isolated from the roots of Boronia pinnata, and their structures were elucidated by NMR and MS analyses. In a search for novel cancer chemopreventive agents (antitumor-promoters), we screened 10 compounds isolated from the plant for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. Boropinic acid (8) and 4'-hydroxy-3'-prenylcinnamaldehyde were observed to significantly inhibit the EBV-EA activation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / pharmacology
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Antiviral Agents / isolation & purification
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Antiviral Agents / pharmacology
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Australia
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Epstein-Barr Virus Nuclear Antigens / metabolism
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Herpesvirus 4, Human / drug effects
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Lignans / chemistry
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Lignans / isolation & purification
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Lignans / pharmacology
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Magnetic Resonance Spectroscopy
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Magnoliopsida / chemistry*
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Plant Roots / chemistry
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Plants, Medicinal / chemistry
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Quinolones / chemistry
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Quinolones / isolation & purification
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Quinolones / pharmacology
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Terpenes / chemistry
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Terpenes / isolation & purification
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Terpenes / pharmacology
Substances
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Alkaloids
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Antiviral Agents
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Epstein-Barr Virus Nuclear Antigens
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Lignans
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Quinolones
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Terpenes