HLA-DQB1*0501-restricted Th1 type immune responses to Plasmodium falciparum liver stage antigen 1 protect against malaria anemia and reinfections

J Infect Dis. 2001 Jan 1;183(1):168-72. doi: 10.1086/317642. Epub 2000 Nov 10.


Protective immunity against Plasmodium falciparum requires constant exposure to the pathogen. T cell-mediated immune responses are induced by T cell epitopes of pre-erythrocytic stage antigens of P. falciparum and involve HLA-restricted CD4 and CD8 cells. Cytotoxic T cell responses to a conserved epitope of P. falciparum liver stage antigen (LSA) type 1 are restricted by the HLA class I allele Bw53. The role of HLA class II alleles in mediating cellular responses against P. falciparum LSA-1 has not yet been demonstrated. In a longitudinal study performed for >4 years, associations were found between the HLA class II allele DQB1*0501 and protection from malaria anemia and malarial reinfections in Gabonese children. Children carrying DQB1*0501 had a higher frequency of interferon-gamma responses to LSA-1 T cell epitopes, compared with noncarriers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Anemia / etiology
  • Anemia / immunology*
  • Animals
  • Antigens, Protozoan / immunology*
  • Child
  • Child, Preschool
  • Cohort Studies
  • Epitopes / immunology
  • HLA-DR Antigens / immunology*
  • Histocompatibility Testing
  • Humans
  • Infant
  • Interferon-gamma / analysis
  • Malaria, Falciparum / complications
  • Malaria, Falciparum / immunology*
  • Peptides / immunology
  • Plasmodium falciparum / immunology*
  • Recurrence
  • Th1 Cells / immunology*


  • Antigens, Protozoan
  • Epitopes
  • HLA-DR Antigens
  • Peptides
  • liver stage-specific antigen, Plasmodium
  • Interferon-gamma