The authors submit a clinical rectrospective study which covers fifteen years of experience in the field of the anorectal tumours cryodestruction. During the 15 years time interval altogether 720 cryodestructions were performed in 128 patients with a malignant lesion of anorectal region. The fifteen years span includes the period of time from 1983 to 1997. Cryosurgery in malignancies belongs to the complex treatment of tumors. This work statistically shows various combinations of chemotherapy, X-ray therapy and immunotherapy.