Concurrent choroidal melanoma in son and father

Am J Ophthalmol. 2000 Nov;130(5):679-80. doi: 10.1016/s0002-9394(00)00612-7.


Purpose: To report the concurrent occurrence of choroidal melanoma in a son and father.

Methods: Case reports. The likelihood of familial occurrence of uveal melanoma in which father and son are affected was estimated using the principles of probability.

Results: Unilateral choroidal melanoma was diagnosed in a 41-year-old man. Three months later, his 68-year-old father presented with a pigmented choroidal mass that greatly increased in size during the next 6 months and was diagnosed a choroidal melanoma. No personal or family history of atypical moles, cutaneous melanoma, or other malignancy existed. The likelihood of familial occurrence of uveal melanoma using principles of probability was estimated to be 1 in 10 million.

Conclusion: Considering the low prevalence of uveal melanoma in the general population, the likelihood of uveal melanoma occurring in a family setting is remote.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Brachytherapy
  • Choroid Neoplasms / genetics*
  • Choroid Neoplasms / pathology
  • Choroid Neoplasms / radiotherapy
  • Fundus Oculi
  • Humans
  • Iodine Radioisotopes / therapeutic use
  • Male
  • Melanoma / genetics*
  • Melanoma / pathology
  • Melanoma / radiotherapy
  • Pedigree
  • Probability


  • Iodine Radioisotopes