In vivo regulation of precursor cells in the subventricular zone of adult rat brain by thyroid hormone and retinoids

Neurosci Lett. 2000 Dec 1;295(1-2):17-20. doi: 10.1016/s0304-3940(00)01580-9.

Abstract

The mature central nervous system contains precursor cells in the subventricular zone of the lateral ventricle. In this study we examined the possibility to affect fate of precursor cells through exogenous manipulations. The results indicate that administration of thyroid hormone and retinoic acid increases the expression of Ki67, a nuclear antigen associated with cell proliferation, and of nestin, a marker protein for precursor cells in the subventricular zone of adult male rats. Moreover, retinoic acid increases polysialated-neural cell adhesion molecules (PSA-NCAM)-immunoreactivity. These data suggest that nuclear receptor ligands are potential candidates for fate determination of precursor cells in the subventricular zone also in the adult brain.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology*
  • Biomarkers
  • Intermediate Filament Proteins / drug effects*
  • Intermediate Filament Proteins / metabolism
  • Ki-67 Antigen / drug effects*
  • Ki-67 Antigen / metabolism
  • Lateral Ventricles / cytology
  • Lateral Ventricles / drug effects*
  • Lateral Ventricles / metabolism
  • Male
  • Nerve Tissue Proteins*
  • Nestin
  • Neural Cell Adhesion Molecules / drug effects*
  • Neural Cell Adhesion Molecules / metabolism
  • Rats
  • Rats, Sprague-Dawley
  • Thyroid Hormones / pharmacology*
  • Tretinoin / pharmacology*

Substances

  • Antineoplastic Agents
  • Biomarkers
  • Intermediate Filament Proteins
  • Ki-67 Antigen
  • Nerve Tissue Proteins
  • Nes protein, rat
  • Nestin
  • Neural Cell Adhesion Molecules
  • Thyroid Hormones
  • Tretinoin

Grant support