Simocyclinones, novel cytostatic angucyclinone antibiotics produced by Streptomyces antibioticus Tü 6040. I. Taxonomy, fermentation, isolation and biological activities

J Antibiot (Tokyo). 2000 Aug;53(8):779-87. doi: 10.7164/antibiotics.53.779.

Abstract

Two novel angucyclinone-type antibiotics, simocyclinones D4 and D8, were detected in the mycelium extract of Streptomyces antibioticus Tü 6040 by HPLC-diode-array and HPLC-electrospray-mass-spectrometry screening. The compounds show antibiotic activities against Gram-positive bacteria and cytostatic effects on various tumor cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / metabolism
  • Anti-Bacterial Agents / pharmacology*
  • Antibiotics, Antineoplastic / pharmacology
  • Coumarins / isolation & purification
  • Coumarins / metabolism
  • Coumarins / pharmacology
  • Drug Screening Assays, Antitumor
  • Fermentation
  • Glycosides / isolation & purification
  • Glycosides / metabolism
  • Glycosides / pharmacology
  • Humans
  • Inhibitory Concentration 50
  • Microbial Sensitivity Tests
  • Streptomyces antibioticus / classification
  • Streptomyces antibioticus / metabolism*
  • Tumor Cells, Cultured

Substances

  • Anti-Bacterial Agents
  • Antibiotics, Antineoplastic
  • Coumarins
  • Glycosides
  • simocyclinone D4
  • simocyclinone D8