Identification of an NADH-linked disulfide reductase from Bacillus megaterium specific for disulfides containing pantethine 4',4''-diphosphate moieties

J Biol Chem. 1979 Aug 10;254(15):6835-7.

Abstract

Bacillus megaterium contains an NADH-linked disulfide reductase that is specific for disulfides containing pantethine 4',4''-diphosphate moieties. This reductase is at its highest level in cells late in sporulation and in dormant spores, and could be involved in the formation and cleavage of coenzyme A-protein disulfides which take place late in sporulation and early in spore germination, respectively.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Bacillus megaterium / enzymology*
  • Disulfides
  • Kinetics
  • NADH, NADPH Oxidoreductases / isolation & purification
  • NADH, NADPH Oxidoreductases / metabolism*
  • Pantetheine / analogs & derivatives
  • Spores, Bacterial / enzymology
  • Substrate Specificity

Substances

  • Disulfides
  • pantethine 4',4''-diphosphate
  • Pantetheine
  • NADH, NADPH Oxidoreductases