Abstract
Up to half of parous females with bipolar disorder (manic depression) develop an episode of severe psychiatric disturbance, usually called puerperal psychosis, within a few days of giving birth. We report significant evidence (p<0.003) that variation at the serotonin transporter gene exerts a substantial (odds ratio=4) and important (population attributable fraction=69%) influence on susceptibility to such episodes.
Publication types
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Comparative Study
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Alleles
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Bipolar Disorder / genetics*
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Carrier Proteins / genetics*
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DNA / genetics
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Female
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Gene Frequency
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Genetic Predisposition to Disease
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Genetic Variation
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Genotype
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Humans
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Membrane Glycoproteins / genetics*
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Membrane Transport Proteins*
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Middle Aged
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Nerve Tissue Proteins*
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Odds Ratio
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Polymorphism, Genetic
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Psychotic Disorders / genetics
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Puerperal Disorders / genetics*
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Serotonin Plasma Membrane Transport Proteins
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Tandem Repeat Sequences / genetics
Substances
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Carrier Proteins
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Membrane Glycoproteins
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Membrane Transport Proteins
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Nerve Tissue Proteins
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SLC6A4 protein, human
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Serotonin Plasma Membrane Transport Proteins
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DNA