Regulation and functions of Rho-associated kinase

Exp Cell Res. 2000 Nov 25;261(1):44-51. doi: 10.1006/excr.2000.5046.

Abstract

Remarkable progress has been made in understanding effector molecules of small GTPase Rho, especially Rho-associated kinase (Rho-kinase/ROK/ROCK), in the past 5 years. Rho-associated kinase appears to mediate a large proportion of the signals from Rho and regulate dynamic reorganization of cytoskeletal proteins, such as stress fiber and focal adhesion formation. Several substrates of Rho-associated kinase have been reported and their cellular functions unraveled. In this review, we focus on the regulation and cellular functions of Rho-associated kinase.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Movement
  • Cytoskeletal Proteins / chemistry
  • Cytoskeletal Proteins / metabolism
  • Cytoskeleton / physiology
  • Cytoskeleton / ultrastructure
  • Growth Cones / physiology
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Protein-Serine-Threonine Kinases / genetics*
  • Protein-Serine-Threonine Kinases / metabolism*
  • Signal Transduction
  • rho-Associated Kinases

Substances

  • Cytoskeletal Proteins
  • Intracellular Signaling Peptides and Proteins
  • Protein-Serine-Threonine Kinases
  • rho-Associated Kinases