Molecular domains of myelinated axons

Curr Opin Neurobiol. 2000 Oct;10(5):558-65. doi: 10.1016/s0959-4388(00)00122-7.


Myelinated axons are organized into specific domains as the result of interactions with glial cells. Recently, distinct protein complexes of cell adhesion molecules, Na(+) channels and ankyrin G at the nodes, Caspr and contactin in the paranodes, and K(+) channels and Caspr2 in the juxtaparanodal region have been identified, and new insights into the role of the paranodal junctions in the organization of these domains have emerged.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Axons / chemistry
  • Axons / metabolism*
  • Axons / ultrastructure
  • Humans
  • Ion Channels / metabolism
  • Ion Channels / physiology
  • Myelin Sheath / chemistry
  • Myelin Sheath / metabolism*
  • Nerve Tissue Proteins / chemistry
  • Nerve Tissue Proteins / metabolism*


  • Ion Channels
  • Nerve Tissue Proteins