Tetracycline-regulated gene expression in the brain

Curr Opin Neurobiol. 2000 Oct;10(5):593-6. doi: 10.1016/s0959-4388(00)00127-6.


The possibility of regulating individual gene activities in the mouse brain via the tetracycline-controlled transcriptional activation systems has sparked the development of novel mouse models aimed at elucidating the molecular mechanisms of brain disorders such as Huntington's, prion and Parkinson's diseases. In the past year, novel experimental strategies and methodological advances have emerged, contributing to the resolution of some of the initial limitations of these regulatory systems.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain Chemistry / drug effects*
  • Brain Chemistry / genetics*
  • Gene Expression / drug effects*
  • Humans
  • Nerve Tissue Proteins / biosynthesis
  • Neurodegenerative Diseases / genetics
  • Neurodegenerative Diseases / metabolism
  • Protein Synthesis Inhibitors / pharmacology*
  • Tetracycline / pharmacology*


  • Nerve Tissue Proteins
  • Protein Synthesis Inhibitors
  • Tetracycline