Cytoskeleton: functions for tubulin modifications at last

Curr Biol. 2000 Nov 2;10(21):R801-3. doi: 10.1016/s0960-9822(00)00767-3.

Abstract

New studies show that three types of evolutionarily conserved post translational tubulin modification, polyglutamylation, polyglycylation and detyrosination, play important roles in vivo. These modifications appear to act by modulating the binding of molecular motors to the external surface of microtubules.

Publication types

  • Review

MeSH terms

  • Animals
  • Microtubules / chemistry
  • Microtubules / immunology
  • Microtubules / metabolism*
  • Molecular Motor Proteins / metabolism
  • Mutation
  • Protein Binding
  • Protein Processing, Post-Translational*
  • Tetrahymena / genetics
  • Tetrahymena / metabolism
  • Tubulin / chemistry*
  • Tubulin / genetics
  • Tubulin / metabolism*

Substances

  • Molecular Motor Proteins
  • Tubulin