Review
doi: 10.1016/s0968-0004(00)01681-9.
Ubiquitin in chains
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- PMID: 11084366
- DOI: 10.1016/s0968-0004(00)01681-9
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Review
Ubiquitin in chains
Trends Biochem Sci.
2000 Nov.
Free article
Abstract
The ubiquitin-proteasome system fulfills an essential function in eukaryotes by controlling the levels of crucial intracellular regulatory proteins. In this system, a specific type of polyubiquitin chain acts as the proximal signal for targeting substrates to 26S proteasomes for degradation. Recent results have revealed important determinants of polyubiquitin-chain recognition by proteasomes, helping to explain the biological rationale behind this novel signaling mechanism.
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