Topical cocaine and general anaesthesia: an investigation of the efficacy and side effects of cocaine on the nasal mucosae

Anaesthesia. 1975 Nov;30(6):809-17. doi: 10.1111/j.1365-2044.1975.tb00962.x.


A double-blind investigation has been carried out using three different doses (20, 35 and 50 mg) of cocaine which were sprayed onto the nasal mucous membranes of forty-five patients for nasal surgery. The cocaine was administered after induction of general anaesthesia in all cases. The 20 mg dose of cocaine dissolved in 2 ml of saline without adrenaline was found to be safe and produced adequate nasal decongestion in the absence of other predominant factors. The efficacy of cocaine and its safety with regard to systemic absorption are assessed.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Administration, Topical
  • Adolescent
  • Adult
  • Aged
  • Anesthesia, General
  • Blood Pressure / drug effects
  • Clinical Trials as Topic
  • Cocaine / administration & dosage
  • Cocaine / pharmacology*
  • Hemorrhage
  • Humans
  • Middle Aged
  • Nasal Mucosa / drug effects*
  • Nasal Mucosa / surgery
  • Pulse / drug effects
  • Sodium Chloride


  • Sodium Chloride
  • Cocaine