Cytotoxic constituents of Polyalthia longifolia var. pendula

C Y Chen; F R Chang; Y C Shih; T J Hsieh; Y C Chia; H Y Tseng; H C Chen; S J Chen; M C Hsu; Y C Wu

doi:10.1021/np000176e

Cytotoxic constituents of Polyalthia longifolia var. pendula

J Nat Prod. 2000 Nov;63(11):1475-8. doi: 10.1021/np000176e.

Authors

C Y Chen¹, F R Chang, Y C Shih, T J Hsieh, Y C Chia, H Y Tseng, H C Chen, S J Chen, M C Hsu, Y C Wu

Affiliation

¹ Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

PMID: 11087586
DOI: 10.1021/np000176e

Abstract

A new halimane diterpene, 3beta,5beta, 16alpha-trihydroxyhalima-13(14)-en-15,16-olide (1), and a new oxoprotoberberine alkaloid, (-)-8-oxopolyalthiaine (2), along with 20 known compounds, were isolated from a methanolic extract of Polyalthia longifolia var. pendula. The structures of compounds 1 and 2 were established by spectroscopic analysis. Several of these compounds were evaluated for cytotoxicity toward a small panel of human cell lines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / isolation & purification*
Alkaloids / pharmacology
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology
Berberine Alkaloids*
Diterpenes / isolation & purification*
Diterpenes / pharmacology
Drug Screening Assays, Antitumor
Humans
Magnetic Resonance Spectroscopy
Plant Extracts / chemistry
Plant Extracts / pharmacology
Plants, Medicinal / chemistry*
Spectrophotometry, Ultraviolet
Tumor Cells, Cultured

Substances

3,5,16-trihydroxyhalima-13(14)-en-15,16-olide
8-oxopolyalthiaine
Alkaloids
Antineoplastic Agents, Phytogenic
Berberine Alkaloids
Diterpenes
Plant Extracts