HIV-Inhibitory prenylated xanthones and flavones from Maclura tinctoria

J Nat Prod. 2000 Nov;63(11):1537-9. doi: 10.1021/np000175m.

Abstract

The organic extract of the plant Maclura tinctoria exhibited moderate anti-HIV activity. Seven prenylated phenolic derivatives were isolated from the active fractions and characterized by spectroanalytical methods. New compounds macluraxanthone B (1), macluraxanthone C (2), and dihydrocudraflavone B (8) were identified.

MeSH terms

  • Anti-HIV Agents / isolation & purification*
  • Anti-HIV Agents / pharmacology*
  • Chloroform
  • Chromatography, Gel
  • Chromatography, High Pressure Liquid
  • Flavonoids / isolation & purification*
  • Flavonoids / pharmacology*
  • HIV / drug effects
  • Magnetic Resonance Spectroscopy
  • Microbial Sensitivity Tests
  • Plant Extracts / analysis
  • Plants, Medicinal / chemistry*
  • Spectrophotometry, Ultraviolet
  • Xanthenes / isolation & purification*
  • Xanthenes / pharmacology
  • Xanthines / isolation & purification*
  • Xanthines / pharmacology*
  • Xanthones*

Substances

  • Anti-HIV Agents
  • Flavonoids
  • Plant Extracts
  • Xanthenes
  • Xanthines
  • Xanthones
  • dihydrocudraflavone B
  • macluraxanthone B
  • macluraxanthone C
  • Chloroform