Multiple seizure susceptibility genes on chromosome 7 in SWXL-4 congenic mouse strains

Genomics. 2000 Nov 15;70(1):62-5. doi: 10.1006/geno.2000.6368.


The SWXL-4 recombinant inbred mouse strain is unusually sensitive to recurrent tonic-clonic seizures upon routine handling and to seizures induced by chemoconvulsants. In a conventional intercross with the ABP/Le strain, we previously mapped a SWXL-4-derived quantitative trait locus called Szf1 (seizure frequency 1) to Chromosome 7. In the present study, we confirm the existence of Szf1 in both an independent cross and a congenic strain. However, derivative congenic recombinant strains show that an interaction between at least two genes on Chromosome 7-each of which has a very small effect on its own-account for Szf1.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Crosses, Genetic
  • Genetic Predisposition to Disease
  • Mice
  • Mice, Congenic
  • Mice, Inbred Strains
  • Quantitative Trait, Heritable
  • Seizures / genetics*