Misleading results with the 14-3-3 assay for the diagnosis of Creutzfeldt-Jakob disease

Neurology. 2000 Nov 14;55(9):1396-7. doi: 10.1212/wnl.55.9.1396.

Abstract

The definitive diagnosis of Creutzfeldt-Jakob disease (CJD) requires brain tissue analysis. A positive assay for the 14-3-3 protein in CSF has been suggested to be highly sensitive and specific in patients with CJD. The authors describe three patients for whom CSF 14-3-3 assays were falsely positive or falsely negative. Caution against overreliance on this putative biomarker is suggested in the diagnosis of CJD.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 14-3-3 Proteins
  • Adult
  • Creutzfeldt-Jakob Syndrome / cerebrospinal fluid*
  • False Negative Reactions
  • Female
  • Humans
  • Male
  • Middle Aged
  • Tyrosine 3-Monooxygenase / cerebrospinal fluid*

Substances

  • 14-3-3 Proteins
  • Tyrosine 3-Monooxygenase