Post-transcriptional gene silencing across kingdoms

Curr Opin Genet Dev. 2000 Dec;10(6):638-43. doi: 10.1016/s0959-437x(00)00134-9.


Post-transcriptional gene silencing (PTGS) as a consequence of the introduction of either transgenes or double-stranded RNA molecules has been found to occur in a number of species. In the past year, studies in different systems have greatly enhanced our understanding of the molecular mechanisms of these phenomena. The ubiquitous presence of PTGS in both the plant and animal kingdoms and the finding of common genetic mechanisms suggest that PTGS is a universal gene-regulation system fundamental in biological processes such as protection against viruses and transposons.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animal Population Groups / genetics
  • Animals
  • Biological Evolution
  • Gene Silencing*
  • Genome
  • Models, Genetic
  • Plants / genetics
  • RNA Processing, Post-Transcriptional*
  • RNA, Double-Stranded
  • RNA, Viral
  • Transgenes


  • RNA, Double-Stranded
  • RNA, Viral