Endogenous retroviruses and the human germline

Curr Opin Genet Dev. 2000 Dec;10(6):651-5. doi: 10.1016/s0959-437x(00)00138-6.


The human genome is rife with the proviral remains of many ancient retroviruses. The past year has seen significant progress in understanding the structure, distribution and potential function of many of these elements. Although hypotheses concerning the potential effects of these elements are common, however, incisive experiments to test any functions remain much less so.

Publication types

  • Review

MeSH terms

  • Animals
  • Endogenous Retroviruses / classification
  • Endogenous Retroviruses / genetics*
  • Evolution, Molecular
  • Genetic Code
  • Genome, Human*
  • Germ-Line Mutation*
  • Humans
  • Phylogeny
  • Proviruses / classification
  • Proviruses / genetics*