Retinoblastoma-related proteins in plants: homologues or orthologues of their metazoan counterparts?

Plant Mol Biol. 2000 Aug;43(5-6):635-42. doi: 10.1023/a:1006426808185.


The mammalian retinoblastoma tumor suppressor protein (pRb) regulates cell division, differentiation and apoptotic pathways in specific cell types. In association with other proteins, pRb acts in part by modulating transcriptional activity. Elements of the pRb regulatory network have been identified in higher plants. Recent findings involving these proteins, which display amino acid sequence homology and biochemical binding properties analogous to their mammalian counterparts, are discussed.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Carrier Proteins*
  • Cell Cycle
  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / metabolism
  • Cell Differentiation
  • DNA-Binding Proteins*
  • E2F Transcription Factors
  • Gene Expression Regulation, Developmental
  • Genes, Plant*
  • Molecular Sequence Data
  • Phosphorylation
  • Plant Development
  • Plants / genetics*
  • Retinoblastoma Protein / genetics*
  • Retinoblastoma Protein / metabolism
  • Retinoblastoma-Binding Protein 1
  • Transcription Factors / genetics
  • Transcription Factors / metabolism


  • Carrier Proteins
  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • E2F Transcription Factors
  • Retinoblastoma Protein
  • Retinoblastoma-Binding Protein 1
  • Transcription Factors

Associated data

  • GENBANK/AF133675