Why do we age?

Nature. 2000 Nov 9;408(6809):233-8. doi: 10.1038/35041682.


The evolutionary theory of ageing explains why ageing occurs, giving valuable insight into the mechanisms underlying the complex cellular and molecular changes that contribute to senescence. Such understanding also helps to clarify how the genome shapes the ageing process, thereby aiding the study of the genetic factors that influence longevity and age-associated diseases.

Publication types

  • Review

MeSH terms

  • Aging / genetics
  • Aging / physiology*
  • Animals
  • Biological Evolution*
  • Energy Intake
  • Humans
  • Models, Biological
  • Reproduction
  • Selection, Genetic