Genetic pathways that regulate ageing in model organisms

Nature. 2000 Nov 9;408(6809):255-62. doi: 10.1038/35041700.


Searches for genes involved in the ageing process have been made in genetically tractable model organisms such as yeast, the nematode Caenorhabditis elegans, Drosophila melanogaster fruitflies and mice. These genetic studies have established that ageing is indeed regulated by specific genes, and have allowed an analysis of the pathways involved, linking physiology, signal transduction and gene regulation. Intriguing similarities in the phenotypes of many of these mutants indicate that the mutations may also perturb regulatory systems that control ageing in higher organisms.

Publication types

  • Review

MeSH terms

  • Aging / genetics*
  • Animals
  • Caenorhabditis elegans
  • Drosophila Proteins*
  • Drosophila melanogaster
  • Energy Intake
  • Gene Silencing
  • Histone Deacetylases / physiology
  • Hormones / physiology
  • Longevity
  • Mutation
  • Neurons, Afferent / physiology
  • Reproduction
  • Signal Transduction
  • Silent Information Regulator Proteins, Saccharomyces cerevisiae*
  • Sirtuin 2
  • Sirtuins
  • Trans-Activators / physiology
  • Yeasts


  • Drosophila Proteins
  • Hormones
  • Silent Information Regulator Proteins, Saccharomyces cerevisiae
  • Trans-Activators
  • SIR2 protein, S cerevisiae
  • Sirt2 protein, Drosophila
  • Sirtuin 2
  • Sirtuins
  • Histone Deacetylases