Sequential evaluation of left ventricular myocardial performance in children after anthracycline therapy

Am J Cardiol. 2000 Dec 1;86(11):1279-81, A9. doi: 10.1016/s0002-9149(00)01222-4.


This study prospectively assessed subclinical cardiotoxicity in patients undergoing chemotherapy by using the Tei index combining systolic and diastolic time intervals. A significant difference in the Tei index was observed between patients who received a low dose and those who received a moderate to high dose of anthracycline antibiotic drugs. The Tei index is a sensitive, accurate, and easy approach for detecting subclinical anthracycline cardiotoxicity.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Antibiotics, Antineoplastic / adverse effects*
  • Blood Flow Velocity / drug effects
  • Child
  • Echocardiography, Doppler
  • Humans
  • Mediastinal Neoplasms / drug therapy*
  • Myocardial Contraction / drug effects
  • Observer Variation
  • Prognosis
  • Prospective Studies
  • Stroke Volume / drug effects
  • Ventricular Dysfunction, Left / chemically induced
  • Ventricular Dysfunction, Left / diagnostic imaging
  • Ventricular Dysfunction, Left / physiopathology*


  • Antibiotics, Antineoplastic