The potential of Artemisia annua L. as a locally produced remedy for malaria in the tropics: agricultural, chemical and clinical aspects

J Ethnopharmacol. 2000 Dec;73(3):487-93. doi: 10.1016/s0378-8741(00)00289-0.


The plant Artemisia annua L. (Asteraceae) is listed in the Chinese pharmacopoeia as a remedy for various fevers including malaria, and contains the well-established antimalarial compound artemisinin. In this study, a hybrid form of A. annua was successfully cultivated in Central Africa. The aerial parts of the plant contained 0.63-0.70% artemisinin per dry weight, and approximately 40% of this artemisinin could be extracted by simple tea preparation methods. Five malaria patients who were treated with A. annua tea showed a rapid disappearance of parasitaemia within 2-4 days. An additional trial with 48 malaria patients showed a disappearance of parasitaemia in 44 patients (92%) within 4 days. Both trials showed a marked improvement of symptoms. In our opinion, these results justify further examinations of the antimalarial effect of A. annua preparations.

MeSH terms

  • Artemisia / chemistry*
  • Artemisinins*
  • Humans
  • Lactones / therapeutic use
  • Malaria / therapy*
  • Plants, Medicinal*
  • Sesquiterpenes / therapeutic use
  • Tea
  • Tropical Climate


  • Artemisinins
  • Lactones
  • Sesquiterpenes
  • Tea
  • artemisin