Lipoatrophy revisited

Trends Endocrinol Metab. 2000 Dec;11(10):410-6. doi: 10.1016/s1043-2760(00)00309-x.


The lipoatrophy syndromes are a heterogeneous group of syndromes characterized by a paucity of adipose tissue. Severe lipoatrophy is associated with insulin-resistant diabetes mellitus (DM). The loss of adipose tissue can have a genetic, immune, or infectious/drug-associated etiology. Causative mutations have been identified in patients for one form of partial lipoatrophy--Dunnigan-type familial partial lipodystrophy. Experiments using lipoatrophic mice demonstrate that the diabetes results from the lack of fat and that leptin deficiency is a contributing factor. Thiazolidinedione therapy improves metabolic control in lipoatrophic patients; the efficacy of leptin treatment is currently being investigated.

Publication types

  • Review

MeSH terms

  • Adipose Tissue / pathology
  • Adipose Tissue / physiopathology*
  • Animals
  • Diabetes Mellitus, Lipoatrophic / genetics
  • Diabetes Mellitus, Lipoatrophic / physiopathology*
  • Humans
  • Mice