Treatment of chronic daily posttraumatic headache with divalproex sodium

Headache. 2000 Oct;40(9):736-9. doi: 10.1046/j.1526-4610.2000.00128.x.


Objective: To determine the effectiveness of divalproex sodium in the treatment of chronic daily posttraumatic headaches.

Background: Divalproex sodium has been found to be useful for the treatment of migraine and chronic daily headache. No studies have been done to evaluate effectiveness in posttraumatic headache.

Methods: A retrospective review was done of 100 patients treated with divalproex for chronic daily posttraumatic headache of 2 months or longer.

Results: Sixty percent of patients with chronic posttraumatic headache had mild to moderate improvement in their headaches after at least 1 month of divalproex sodium. Forty percent either showed no response (26%) or discontinued treatment because of side effects (14%). Fifty-eight percent of patients showing improvement had a change in headache pattern from daily to episodic.

Conclusions: Divalproex sodium appears to be safe and effective for treatment of patients with persistent, chronic daily posttraumatic headaches.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chronic Disease
  • Craniocerebral Trauma / complications*
  • Follow-Up Studies
  • GABA Agents / therapeutic use*
  • Headache / drug therapy*
  • Headache / etiology*
  • Humans
  • Recurrence
  • Retrospective Studies
  • Time Factors
  • Treatment Outcome
  • Valproic Acid / therapeutic use*


  • GABA Agents
  • Valproic Acid