Systemic sclerosis: environmental and occupational risk factors

Curr Opin Rheumatol. 2000 Nov;12(6):520-6. doi: 10.1097/00002281-200011000-00008.


There is growing concern about the association between systemic sclerosis and certain environmental and occupational risk factors, including exposures to vinyl chloride, adulterated cooking oils, L-tryptophan, silica, silicone breast implants, organic solvents, and other agents such as epoxy resins, pesticides, and hand/arm vibration. This article highlights the current medical research that has examined these associations in scleroderma-like disorders and in systemic sclerosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Environmental Exposure / adverse effects
  • Humans
  • Occupational Exposure / adverse effects
  • Risk Factors
  • Scleroderma, Systemic* / epidemiology
  • Scleroderma, Systemic* / etiology