Assessment of damage and activity in systemic sclerosis

Curr Opin Rheumatol. 2000 Nov;12(6):545-8. doi: 10.1097/00002281-200011000-00012.


The determination of damage and activity in the course of a disease are important matters. Monitoring damage activity is critical in the evaluation of individual patients and in evaluating treatment efficacy in clinical trials. A disease damage (severity) scale has been published for systemic sclerosis. A number of potential cytokine and other soluble protein markers of disease activity for this disease have been proposed in recent publications, reviewed here.

Publication types

  • Review

MeSH terms

  • Acute-Phase Proteins / analysis
  • Disease Progression
  • Humans
  • Scleroderma, Systemic / physiopathology*
  • Severity of Illness Index


  • Acute-Phase Proteins