Abstract
Spraying or swabbing with a mixture of polyethylene glycol 300/industrial methylated spirits (PEG-300/IMS) (2:1 by volume) has been shown to substantially reduce mortality, systemic effects, and skin burns resulting from skin contamination by phenol, cumene hydroperoxide, or phenol/acetone cleavage product. The skin-damaging potentials of sodium hydroxide and sulfuric acid have also been investigated. PEG-300/IMS(2:1 by volume) mixture was found, in rats, to be slightly less effective than water as means of decontamination. The PEG-300/IMS mixture has been shown not to cause eye irritation, and so should not present a hazard where this mixture is used as a decontaminant spray.
MeSH terms
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Acetone / toxicity
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Alkanes / therapeutic use
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Animals
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Benzyl Compounds / toxicity
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Burns, Chemical / complications
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Burns, Chemical / etiology
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Burns, Chemical / therapy*
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Decontamination / methods*
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Detergents / administration & dosage
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Detergents / therapeutic use
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Eye / drug effects
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Glycerol / therapeutic use
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Lethal Dose 50
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Methanol / administration & dosage
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Methanol / therapeutic use
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Occupational Medicine*
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Peroxides / toxicity*
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Phenols / toxicity*
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Polyethylene Glycols / administration & dosage
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Polyethylene Glycols / pharmacology
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Polyethylene Glycols / therapeutic use*
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Quaternary Ammonium Compounds / administration & dosage
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Quaternary Ammonium Compounds / therapeutic use
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Rabbits
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Rats
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Skin Absorption / drug effects
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Sodium Hydroxide / toxicity
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Sulfuric Acids / toxicity
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Water
Substances
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Alkanes
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Benzyl Compounds
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Detergents
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Peroxides
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Phenols
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Quaternary Ammonium Compounds
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Sulfuric Acids
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Water
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Acetone
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Polyethylene Glycols
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Sodium Hydroxide
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Glycerol
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Methanol