A recQ family DNA helicase gene from Aspergillus nidulans

DNA Seq. 2000;11(3-4):315-9.

Abstract

We have identified an Aspergillus nidulans gene encoding a RecQ family helicase which we have therefore named recQ. The A. nidulans recQ protein is most closely related in sequence to human recQ helicase 5. Like the latter polypeptide, A. nidulans recQ consists of little more than the conserved helicase domain, lacking the long amino- and carboxy-terminal extensions seen in other recQ family members such as BLM and WRN and in the sole RecQ family helicase of the yeast Saccharomyces cerevisiae (Sgs1p). By analogy with other eukaryotic RecQ helicases, A. nidulans recQ helicase is likely to play an important role in the maintenance of genomic integrity.

MeSH terms

  • Adenosine Triphosphatases / chemistry
  • Adenosine Triphosphatases / genetics*
  • Amino Acid Sequence
  • Aspergillus nidulans / enzymology*
  • Aspergillus nidulans / genetics*
  • Base Sequence
  • Bloom Syndrome / genetics
  • Conserved Sequence
  • DNA Helicases / chemistry
  • DNA Helicases / genetics*
  • Humans
  • Molecular Sequence Data
  • Promoter Regions, Genetic
  • RecQ Helicases
  • Saccharomyces cerevisiae / enzymology
  • Saccharomyces cerevisiae / genetics
  • Sequence Alignment
  • Sequence Homology, Amino Acid

Substances

  • Adenosine Triphosphatases
  • Bloom syndrome protein
  • RECQL protein, human
  • DNA Helicases
  • RecQ Helicases

Associated data

  • GENBANK/AJ271844