Complex trait analysis in the mouse: The strengths, the limitations and the promise yet to come

Annu Rev Genet. 2000;34:653-686. doi: 10.1146/annurev.genet.34.1.653.


In 1990, David Baltimore predicted that the 1990s would be the decade of the mouse (). This certainly proved to be true: The mouse has contributed immensely to biological research through transgenic, embryonic stem cell (ES) knockout, and classical genetic technologies. But its usefulness as a model organism is by no means over; indeed it is still rising to its peak: The mouse as a model mammalian organism still has much to offer. This article reviews use of the mouse to dissect complex genetic traits using quantitative trait analysis, with a particular emphasis on medically important diseases.

Publication types

  • Review

MeSH terms

  • Animals
  • Chromosome Mapping
  • Humans
  • Mice
  • Models, Animal
  • Quantitative Trait, Heritable*