An approach to multi-copy search in molecular replacement

Acta Crystallogr D Biol Crystallogr. 2000 Dec;56(Pt 12):1622-4. doi: 10.1107/s0907444900013780.


The molecular-replacement method has been extended to a simultaneous search for multiple copies of the macromolecule in the unit cell. The central point of this approach is the construction of a multi-copy search model from the properly oriented monomers using a special translation function. The multi-copy search method has been implemented in the program MOLREP and successfully tested using experimental data.

MeSH terms

  • Algorithms*
  • Calcium-Binding Proteins / chemistry
  • Crystallography / methods*
  • Crystallography, X-Ray
  • Humans
  • Immunoglobulin Fab Fragments / chemistry
  • Models, Theoretical
  • Nerve Growth Factors / chemistry
  • Protein Conformation
  • S100 Calcium Binding Protein beta Subunit
  • S100 Proteins*
  • Software*


  • Calcium-Binding Proteins
  • Immunoglobulin Fab Fragments
  • Nerve Growth Factors
  • S100 Calcium Binding Protein beta Subunit
  • S100 Proteins