Hydroxychloroquine retinopathy despite regular ophthalmologic evaluation: a consecutive series

J Rheumatol. 2000 Nov;27(11):2703-6.


We describe a consecutive series of patients with hydroxychloroquine (HCQ) retinopathy. Their clinical features illustrate that with normal renal function there is no threshold for total dosage for HCQ toxicity; that color vision testing is important; that almost all patients complain of altered central vision as their first symptom; and that a normal optic fundus does not exclude the diagnosis. Finally, HCQ retinopathy may progress even when the agent is stopped.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Antirheumatic Agents / adverse effects*
  • Color Perception / drug effects
  • Female
  • Humans
  • Hydroxychloroquine / adverse effects*
  • Middle Aged
  • Ophthalmology / methods
  • Physical Examination
  • Retinal Diseases / chemically induced*
  • Retinal Diseases / physiopathology
  • Vision, Ocular / drug effects


  • Antirheumatic Agents
  • Hydroxychloroquine