Acute generalized exanthematic pustulosis (AGEP) in a patient treated with furosemide

Am J Med Sci. 2000 Nov;320(5):331-3. doi: 10.1097/00000441-200011000-00006.


Background: Although they appear more rarely than electrolyte disturbances, cutaneous reactions are important adverse effects of furosemide. This is particularly true for bullous skin eruptions, because they may be life-threatening.

Case report: We describe a patient who developed acute generalized exanthematic pustulosis (AGEP) during treatment with furosemide. Because the patient had developed similar skin eruptions during treatment with furosemide years before, furosemide was considered the most likely cause of this reaction. The short period of time between exposure to furosemide and the appearance of the skin reaction, as well as a positive lymphocyte transformation test, suggest an immunological mechanism of the skin disease.

Conclusion: AGEP is a possible cutaneous side effect of furosemide.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Drug Eruptions / pathology*
  • Exanthema / chemically induced*
  • Exanthema / pathology
  • Furosemide / adverse effects*
  • Furosemide / toxicity
  • Humans
  • Male
  • Skin Diseases, Vesiculobullous / chemically induced*
  • Skin Diseases, Vesiculobullous / pathology


  • Furosemide