Fine structure of the auditory M100 in schizophrenia and schizoaffective disorder

Biol Psychiatry. 2000 Dec 1;48(11):1109-12. doi: 10.1016/s0006-3223(00)00941-0.


Background: Several studies have demonstrated anomalous asymmetry of the 100-msec latency auditory-evoked field (M100) in schizophrenia. Recent evidence suggests this may be a compound component, however. Our study examines the localization of two M100 subcomponents in patients with schizophrenia and schizoaffective disorder.

Methods: Magnetoencephalographic recordings of auditory-evoked fields were obtained for 14 subjects with schizophrenia, 12 with schizoaffective disorder, and 23 control subjects. Two M100 subcomponents were identified and localized in each hemisphere.

Results: Both patient groups exhibited different lateralization compared with control subjects, with the second subcomponent tending to be less lateralized.

Conclusions: The second subcomponent may be the major contributor to previously reported laterality differences. Future studies might benefit by separating M100 subcomponents so that specific functions could be addressed.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Analysis of Variance
  • Case-Control Studies
  • Dominance, Cerebral*
  • Evoked Potentials, Auditory*
  • Humans
  • Magnetoencephalography
  • Male
  • Middle Aged
  • Psychotic Disorders / physiopathology*
  • Schizophrenia / physiopathology*