Cell-cycle regulation in immunity, tolerance and autoimmunity

Immunol Today. 2000 Nov;21(11):551-5. doi: 10.1016/s0167-5699(00)01748-5.


To trigger an effective immune response, lymphocytes must proliferate. In addition to their direct involvement in cell-cycle progression, cell-cycle regulators might thus control immune functions. Recent evidence suggests that these regulators are essential for T-cell function; we argue that their study will provide clues for dissecting anergy and tolerance mechanisms, as well as for intervention in autoimmune diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autoimmunity
  • Cell Cycle / immunology*
  • Humans
  • Immune Tolerance
  • Immunity*
  • Lymphocyte Activation
  • Models, Biological