NKT Cells: Facts, Functions and Fallacies

Immunol Today. 2000 Nov;21(11):573-83. doi: 10.1016/s0167-5699(00)01735-7.

Abstract

The proposed roles of NK1.1(+) T (NKT) cells in immune responses range from suppression of autoimmunity to tumor rejection. Heterogeneity of these cells contributes to the controversy surrounding their development and function. This review aims to provide an update on NKT cell biology and, whenever possible, to compare what is known about NKT-cell subsets.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigens, Differentiation / metabolism
  • Autoimmune Diseases / immunology
  • Galactosylceramides / pharmacology
  • Humans
  • Infections / immunology
  • Killer Cells, Natural / classification
  • Killer Cells, Natural / drug effects
  • Killer Cells, Natural / immunology*
  • Ligands
  • Mice
  • Neoplasms / immunology
  • T-Lymphocyte Subsets / drug effects
  • T-Lymphocyte Subsets / immunology*

Substances

  • Antigens, Differentiation
  • Galactosylceramides
  • Ligands