Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 2 (4), 245-8

Physiologic Role of interleukin-1 Receptor Antagonist

Affiliations
Review

Physiologic Role of interleukin-1 Receptor Antagonist

W P Arend et al. Arthritis Res.

Abstract

Recent studies have described the spontaneous development of arthritis or vasculitis in IL-1 receptor antagonist (IL-1Ra) knockout mice bred on specific and different genetic backgrounds. The levels of both secreted and intracellular isoforms of IL-1Ra produced in the rheumatoid joint or in the arterial wall may not be adequate to effectively inhibit the excess amounts of locally produced IL-1. Thus, an imbalance between IL-1 and IL-1Ra may predispose to local inflammatory disease in particular tissues in the presence of other as yet unknown genetically influenced factors.

Similar articles

See all similar articles

Cited by 19 articles

See all "Cited by" articles

References

    1. Gabay C, Smith MF, Jr, Eidlen D, Arend WP. Interleukin 1 receptor antagonist (IL-1Ra) is an acute phase protein. J Clin Invest. 1997;99:2930–2940. - PMC - PubMed
    1. Arend WP. Interleukin-1 receptor antagonist. Adv Immunol . 1993;54:167–227. - PubMed
    1. Arend WP, Malyak M, Guthridge CJ, Gabay C. Interleukin-1 receptor antagonist: role in biology. Annu Rev Immunol. 1998;16:27–55. - PubMed
    1. Horai R, Saijo S, Tanioka H, et al. Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice. J Exp Med. 2000;191:313–320. - PMC - PubMed
    1. Nicklin MJH, Hughes DE, Barton JL, Ure JM, Duff GW. Arterial inflammation in mice lacking the interleukin 1 receptor antagonist gene. . J Exp Med. 2000;191:303–311. - PMC - PubMed

LinkOut - more resources

Feedback