Physiologic role of interleukin-1 receptor antagonist

Arthritis Res. 2000;2(4):245-8. doi: 10.1186/ar94. Epub 2000 May 19.

Abstract

Recent studies have described the spontaneous development of arthritis or vasculitis in IL-1 receptor antagonist (IL-1Ra) knockout mice bred on specific and different genetic backgrounds. The levels of both secreted and intracellular isoforms of IL-1Ra produced in the rheumatoid joint or in the arterial wall may not be adequate to effectively inhibit the excess amounts of locally produced IL-1. Thus, an imbalance between IL-1 and IL-1Ra may predispose to local inflammatory disease in particular tissues in the presence of other as yet unknown genetically influenced factors.

Publication types

  • Review

MeSH terms

  • Animals
  • Arthritis, Rheumatoid / metabolism*
  • Disease Models, Animal
  • Humans
  • Interleukin 1 Receptor Antagonist Protein
  • Interleukin-1 / metabolism*
  • Mice
  • Mice, Knockout
  • Sialoglycoproteins / genetics
  • Sialoglycoproteins / metabolism*
  • Vasculitis / metabolism*

Substances

  • IL1RN protein, human
  • Il1rn protein, mouse
  • Interleukin 1 Receptor Antagonist Protein
  • Interleukin-1
  • Sialoglycoproteins