Fibroblast biology. Development and differentiation of synovial fibroblasts in arthritis

Arthritis Res. 2000;2(5):344-7. doi: 10.1186/ar110. Epub 2000 Jun 8.


Synovial fibroblasts occur as two phenotypes--intimal and subintimal. The specialised intimal phenotype includes expression of uridine diphosphoglucose dehydrogenase (UDPGD), vascular cell adhesion molecule-1 (VCAM-1) and complement decay-accelerating factor (DAF). These gene products contribute to specialised functions relating to tissue movement and leucocyte traffic.

Publication types

  • Review

MeSH terms

  • Animals
  • Arthritis / metabolism*
  • Arthritis / physiopathology
  • Cell Differentiation / immunology*
  • Fibroblasts / metabolism*
  • Humans
  • Synovial Membrane / embryology*
  • Synovial Membrane / metabolism